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In recent years, chemometric tools have been frequently applied to the optimization of analytical methods, considering their advantages such as a reduction in the number of experiments that need be executed resulting in lower reagent consumption and considerably less laboratory work.
Table of Contents
1- Introduction
1-1- Application of multivariate techniques in analytical Chemistry
2-1- Variables in multivariate optimization techniques
2- Box-Behnken design as a tool for multivariate optimization
3- The number of experiments (N) required for the development of BBD
4- Advantages of BBD
5- Applications of BBD
1-5- Investigation of Cr (VI) adsorption onto chemically treated Helianthus aunnus Optimization using Response Surface Methodology
2-5- Optimization of oxidative desulfurization of thiophene using Cu/titanium silicate-1 by box-behnken design
3-5- Determination of vitamin C in drug susing of an optimized novel TCPO–Amplex red–gold/silveralloynanoparticles–H2O2 chemiluminescence method by the Box–Behnken design
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